You are currently viewing amyloid beta protein
amyloid beta protein

amyloid beta protein

 

Description

amino acid sequence
Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly- Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val
General Details
Amyloid β protein fragment 1-40 (Aβ40) is derived from amyloid-β protein (Aβ), which is mapped to human chromosome 21q21. Aβ40 is mainly present in vascular amyloid deposits. Aβ40 contains a C-terminal membrane insertion domain. This reflects the structural transition from the random coil to the α-helical structure in the water-micelle medium.

amyloid
amyloid

Application

Amyloid β protein fragments 1-40 have been used to:

In temperature based compositional studies using Fourier transform infrared/differential scanning calorimetry (FT-IR/DSC) studies
As a reference standard in sandwich-type enzyme immunoassay for quantification of amyloid A4 protein in cerebrospinal fluid of patients with head trauma
As a component of embryonic stem cell medium to inhibit amyloid deposition in fibroblasts
Biochem/Physiol Actions
Amyloid β-protein is neurotrophic and neurotoxic in vivo and in vitro in human and rat neuronal cell cultures. β-amyloid peptides (amino acids 1–42 and 1–43) are key components of chronic plaques and neurofibrillary tangles occurring in the hippocampus, neocortex and amygdala of patients with Alzheimer’s disease.
The amyloid β protein fragment 1-40 (Aβ40) forms cation-based ion channels.
restructuring
For maximum biological activity, dilute the stock to 1 mg/mL in calcium-free PBS and incubate at 37 °C for 4 days.
other notes
H2O. Lyophilized in 0.1% TFA

Summary

Alzheimer’s disease (AD) pathogenesis is widely believed to be driven by the production and deposition of β-amyloid peptide (Aβ). For many years, investigators have been puzzled by the weak to non-existent correlation between the amount of neuritic plaque pathology in the human brain and the degree of clinical dementia. Recent advances in our understanding of the development of amyloid pathology have helped to solve this mystery. Substantial evidence now indicates that the solubility of Aβ, and the amount of Aβ in different pools, may be more closely related to disease status. The composition of these pools of Aβ reflects different populations of amyloid deposits, and correlates definitively with the patient’s clinical status. Imaging technologies, including new amyloid imaging agents based on the chemical composition of histologic dyes, are now making it possible to track disease progression as well as amyloid pathology in a living patient. Interestingly, these approaches indicate that Aβ accumulated in AD is different from that found in animal models. In general, accumulated Aβ is more readily cleared from the brain in animal models, and does not show physical and biochemical characteristics similar to the amyloid found in AD. This raises important issues regarding the development and testing of future therapeutic agents. and does not show the same physical and biochemical characteristics as the amyloid found in AD. This raises important issues regarding the development and testing of future therapeutic agents. and does not show the same physical and biochemical characteristics as the amyloid found in AD. This raises important issues regarding the development and testing of future therapeutic agents.

Keywords: amyloid, β-amyloid precursor protein, Aβ, oligomer, fibril

 

 

Beta Amyloid

MO20004 100 ug
EUR 246

Beta Amyloid

MO22142 100 ul
EUR 435

beta Amyloid 40 protein

30R-3013 500 ug
EUR 327
Description: Purified recombinant beta Amyloid 40 protein

beta Amyloid 42 protein

30R-3014 500 ug
EUR 327
Description: Purified recombinant beta Amyloid 42 protein

Beta Amyloid antibody

70R-51450 100 ul
EUR 287
Description: Purified Polyclonal Beta Amyloid antibody

beta Amyloid antibody

70R-AR020 100 ug
EUR 300
Description: Affinity purified Rabbit polyclonal beta Amyloid antibody

beta Amyloid antibody

70R-BR019 100 ug
EUR 300
Description: Affinity purified Rabbit polyclonal beta Amyloid antibody

beta Amyloid Antibody

35506-100ul 100ul
EUR 390

beta Amyloid antibody

10R-7917 100 ug
EUR 322
Description: Mouse monoclonal beta Amyloid antibody

beta Amyloid antibody

10R-A124a 50 ug
EUR 1011
Description: Mouse monoclonal beta Amyloid antibody

beta Amyloid antibody

20R-AR011 250 ul
EUR 381
Description: Rabbit polyclonal beta Amyloid antibody

beta-Amyloid antibody

22965-100ul 100ul
EUR 390

beta Amyloid antibody

70R-12571 100 ul
EUR 457
Description: Affinity purified Rabbit polyclonal beta Amyloid antibody

beta Amyloid antibody

70R-10624 1 ml
EUR 693
Description: Affinity purified Chicken polyclonal beta Amyloid antibody

Amyloid beta 1-42 Protein

abx060277-100ug 100 ug
EUR 759
  • Shipped within 5-10 working days.

Amyloid beta (A4) Precursor Protein

20-abx260881
  • EUR 3418.00
  • EUR 328.00
  • EUR 230.00
  • 1 mg
  • 20 ug
  • 5 ug
  • Shipped within 5-10 working days.

Amyloid beta Protein (20-29)

20-abx266170
  • EUR 439.00
  • EUR 718.00
  • EUR 328.00
  • 10 mg
  • 25 mg
  • 5 mg
  • Shipped within 5-10 working days.

Amyloid beta Protein (33-42)

20-abx266417
  • EUR 537.00
  • EUR 899.00
  • EUR 384.00
  • 10 mg
  • 25 mg
  • 5 mg
  • Shipped within 5-10 working days.

Amyloid beta-Protein (1-43)

5-00662 4 x 1mg Ask for price

Leave a Reply