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Alpha-1-Antichymotrypsin: Interactions with Chymotrypsin-like Proteins

Summary
The interaction of human plasma alpha-1-antichymotrypsin with serine proteinases from various tissues has been investigated. The protein was found to form stable complexes with pancreatic chymotrypsin, leukocyte cathepsin G and mast cell chymotrypsin. No inhibition of pancreatic trypsin or leukocyte elastase could be demonstrated. With a mixture of both alpha-1-antichymotrypsin and alpha-1-proteinase inhibitors, it was found that the former preferentially inactivated leukocyte cathepsin G, whereas the latter showed a strong preference for pancreatic chymotrypsin.

However, leukocyte elastase was specifically inactivated by an alpha-1-proteinase inhibitor in a 1:1 mixture with chymotrypsin. All these results taken together suggest that one of the primary functions of alpha-1-antichymotrypsin is to inactivate leukocyte cathepsin G, whereas alpha-1-proteinase inhibitors inhibit the activity of other serine proteinases, particularly leukocyte elastase. controls.

antitrypsin genotypes
antitrypsin genotypes

Cytomorphology of solid-pseudopapillary neoplasms:

• Excessive cellular aspirate
• myxoid or hyalinized vascular stalk lined by neoplastic cells
• Fragile granular cytoplasm, indistinct cell border
• round or oval nucleus
• Nuclear groove
• imperceptible nucleoli
• Foam cells, necrotic debris

FNA generates highly extracellular smears, which are composed of a monotonous population of cuboidal cells arranged in loosely connective clusters as individual cells, and, most notably, as a single or multiple layers around vascular structures. in, which is often a myxoid or hyaline material (Fig. 13-7a ). Tumor cells have a delicate granular cytoplasm with indistinct cell boundaries. Nuclei are round to oval with finely dispersed chromatin, smooth or oval nuclear shape and indistinct nuclei (Fig. 13–7b). Mitotic shapes are usually imperceptible. The background may contain abundant blood, foam cells, globules of amorphous myxoid material, and necrotic debris.

 

 

Alpha1-Antitrypsin

A00074.0025 25 ml
EUR 218

Alpha1-Antitrypsin

A20074 2 ml
EUR 79

Antitrypsin protein

30R-1218 100 ug
EUR 349
Description: Purified recombinant Human Antitrypsin protein

alpha1 antitrypsin antibody

10R-8458 100 ul
EUR 393
Description: Mouse monoclonal alpha1 antitrypsin antibody

Alpha1 Antitrypsin Antibody

7009-100
EUR 338

Alpha1 Antitrypsin Antibody

7009-30T
EUR 146

Alpha 1 Antitrypsin Antibody

abx023941-1mg 1 mg
EUR 648
  • Shipped within 5-10 working days.

alpha 1 Antitrypsin Protein

20-abx261417
  • EUR 3418.00
  • EUR 328.00
  • EUR 230.00
  • 1 mg
  • 25 ug
  • 5 ug
  • Shipped within 5-10 working days.

alpha 1 Antitrypsin Protein

20-abx263074
  • EUR 328.00
  • EUR 230.00
  • EUR 1010.00
  • 0.5 mg
  • 100 ug
  • 5 mg
  • Shipped within 5-10 working days.

alpha-1 antitrypsin fragment

A1051-1 1 mg
EUR 108
Description: Alpha-1 antitrypsin (A1AT) (H2N-Leu-Gln-His-Leu-Glu-Asn-Glu-Leu-Thr-His-Asp-Ile-Ile-Thr-Lys-OH), which is known as serum trypsin inhibitor, is a protease inhibitor belonging to the serpin superfamily.

alpha-1 antitrypsin fragment

A1051-10 10 mg
EUR 340
Description: Alpha-1 antitrypsin (A1AT) (H2N-Leu-Gln-His-Leu-Glu-Asn-Glu-Leu-Thr-His-Asp-Ile-Ile-Thr-Lys-OH), which is known as serum trypsin inhibitor, is a protease inhibitor belonging to the serpin superfamily.

alpha-1 antitrypsin fragment

A1051-25 25 mg
EUR 456
Description: Alpha-1 antitrypsin (A1AT) (H2N-Leu-Gln-His-Leu-Glu-Asn-Glu-Leu-Thr-His-Asp-Ile-Ile-Thr-Lys-OH), which is known as serum trypsin inhibitor, is a protease inhibitor belonging to the serpin superfamily.

alpha-1 antitrypsin fragment

A1051-5 5 mg
EUR 224
Description: Alpha-1 antitrypsin (A1AT) (H2N-Leu-Gln-His-Leu-Glu-Asn-Glu-Leu-Thr-His-Asp-Ile-Ile-Thr-Lys-OH), which is known as serum trypsin inhibitor, is a protease inhibitor belonging to the serpin superfamily.

Alpha 1 Antitrypsin antibody

70R-7560 1 mg
EUR 268
Description: Affinity purified Goat polyclonal Alpha 1 Antitrypsin antibody

Human Alpha-1 Antitrypsin

7-06355 100µg Ask for price

Human Alpha-1 Antitrypsin

7-06356 500µg Ask for price

Human Alpha-1 Antitrypsin

7-06357 5mg Ask for price

Alpha 1 antitrypsin Antibody

35507-100ul 100ul
EUR 390

alpha 1 Antitrypsin Antibody

49401-100ul 100ul
EUR 333

alpha 1 Antitrypsin Antibody

49401-50ul 50ul
EUR 239

alpha 1-antitrypsin Antibody

48127-100ul 100ul
EUR 333

alpha 1-antitrypsin Antibody

48127-50ul 50ul
EUR 239

alpha 1 Antitrypsin antibody

10-1883 200 ul
EUR 543
Description: Mouse monoclonal alpha 1 Antitrypsin antibody

alpha 1 Antitrypsin antibody

10-A09A 500 ug
EUR 493
Description: Mouse monoclonal alpha 1 Antitrypsin antibody

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