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Alpha-1-Antichymotrypsin: Interactions with Chymotrypsin-like Proteins

Summary
The interaction of human plasma alpha-1-antichymotrypsin with serine proteinases from various tissues has been investigated. The protein was found to form stable complexes with pancreatic chymotrypsin, leukocyte cathepsin G and mast cell chymotrypsin. No inhibition of pancreatic trypsin or leukocyte elastase could be demonstrated. With a mixture of both alpha-1-antichymotrypsin and alpha-1-proteinase inhibitors, it was found that the former preferentially inactivated leukocyte cathepsin G, whereas the latter showed a strong preference for pancreatic chymotrypsin.

However, leukocyte elastase was specifically inactivated by an alpha-1-proteinase inhibitor in a 1:1 mixture with chymotrypsin. All these results taken together suggest that one of the primary functions of alpha-1-antichymotrypsin is to inactivate leukocyte cathepsin G, whereas alpha-1-proteinase inhibitors inhibit the activity of other serine proteinases, particularly leukocyte elastase. controls.

antitrypsin genotypes
antitrypsin genotypes

Cytomorphology of solid-pseudopapillary neoplasms:

• Excessive cellular aspirate
• myxoid or hyalinized vascular stalk lined by neoplastic cells
• Fragile granular cytoplasm, indistinct cell border
• round or oval nucleus
• Nuclear groove
• imperceptible nucleoli
• Foam cells, necrotic debris

FNA generates highly extracellular smears, which are composed of a monotonous population of cuboidal cells arranged in loosely connective clusters as individual cells, and, most notably, as a single or multiple layers around vascular structures. in, which is often a myxoid or hyaline material (Fig. 13-7a ). Tumor cells have a delicate granular cytoplasm with indistinct cell boundaries. Nuclei are round to oval with finely dispersed chromatin, smooth or oval nuclear shape and indistinct nuclei (Fig. 13–7b). Mitotic shapes are usually imperceptible. The background may contain abundant blood, foam cells, globules of amorphous myxoid material, and necrotic debris.

 

 

Alpha1-Antitrypsin

A20074 2 ml
EUR 79

Alpha1 Antitrypsin Antibody

7009-100
EUR 338

Alpha1 Antitrypsin Antibody

7009-30T
EUR 146

Alpha 1 antitrypsin Antibody

35507-100ul 100ul
EUR 390

Human Alpha-1 Antitrypsin

7-06355 100µg Ask for price

Human Alpha-1 Antitrypsin

7-06356 500µg Ask for price

Human Alpha-1 Antitrypsin

7-06357 5mg Ask for price

Alpha 1 Antitrypsin Antibody

abx023941-1mg 1 mg
EUR 648

alpha 1 Antitrypsin Protein

20-abx261417
  • EUR 3418.00
  • EUR 328.00
  • EUR 230.00
  • 1 mg
  • 25 ug
  • 5 ug

alpha 1 Antitrypsin Protein

20-abx263074
  • EUR 328.00
  • EUR 230.00
  • EUR 1010.00
  • 0.5 mg
  • 100 ug
  • 5 mg

Alpha 1 Antitrypsin Antigen

VAng-Cr3859-3mg 3 mg
EUR 806
Description: Alpha 1 Antitrypsin Antigen, Host/Source: Human Plasma. The purity is ≥95% by SDS-PAGE. It is shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.

alpha 1-antitrypsin Antibody

48127-100ul 100ul
EUR 333

alpha 1-antitrypsin Antibody

48127-50ul 50ul
EUR 239

alpha 1 Antitrypsin Antibody

49401-100ul 100ul
EUR 333

alpha 1 Antitrypsin Antibody

49401-50ul 50ul
EUR 239

alpha-1 antitrypsin fragment

A1051-1 1 mg
EUR 108
Description: Alpha-1 antitrypsin (A1AT) (H2N-Leu-Gln-His-Leu-Glu-Asn-Glu-Leu-Thr-His-Asp-Ile-Ile-Thr-Lys-OH), which is known as serum trypsin inhibitor, is a protease inhibitor belonging to the serpin superfamily.

alpha-1 antitrypsin fragment

A1051-10 10 mg
EUR 340
Description: Alpha-1 antitrypsin (A1AT) (H2N-Leu-Gln-His-Leu-Glu-Asn-Glu-Leu-Thr-His-Asp-Ile-Ile-Thr-Lys-OH), which is known as serum trypsin inhibitor, is a protease inhibitor belonging to the serpin superfamily.

alpha-1 antitrypsin fragment

A1051-25 25 mg
EUR 456
Description: Alpha-1 antitrypsin (A1AT) (H2N-Leu-Gln-His-Leu-Glu-Asn-Glu-Leu-Thr-His-Asp-Ile-Ile-Thr-Lys-OH), which is known as serum trypsin inhibitor, is a protease inhibitor belonging to the serpin superfamily.

alpha-1 antitrypsin fragment

A1051-5 5 mg
EUR 224
Description: Alpha-1 antitrypsin (A1AT) (H2N-Leu-Gln-His-Leu-Glu-Asn-Glu-Leu-Thr-His-Asp-Ile-Ile-Thr-Lys-OH), which is known as serum trypsin inhibitor, is a protease inhibitor belonging to the serpin superfamily.

anti-alpha 1 Antitrypsin

YF-PA13777 100 ug
EUR 403
Description: Rabbit polyclonal to alpha 1 Antitrypsin

Recombinant Alpha-1-Antitrypsin (a1AT)

4-RPB697Hu01
  • EUR 413.60
  • EUR 214.00
  • EUR 1276.00
  • EUR 492.00
  • EUR 884.00
  • EUR 340.00
  • EUR 3040.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Alpha-1-Antitrypsin expressed in: E.coli

Recombinant Alpha-1-Antitrypsin (a1AT)

4-RPB697Mu01
  • EUR 458.40
  • EUR 226.00
  • EUR 1444.00
  • EUR 548.00
  • EUR 996.00
  • EUR 370.00
  • EUR 3460.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Alpha-1-Antitrypsin expressed in: E.coli

Recombinant Alpha-1-Antitrypsin (a1AT)

4-RPB697Ra01
  • EUR 368.80
  • EUR 202.00
  • EUR 1108.00
  • EUR 436.00
  • EUR 772.00
  • EUR 310.00
  • EUR 2620.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat Alpha-1-Antitrypsin expressed in: E.coli

Recombinant Antitrypsin Related Protein (ATR)

4-RPD751Hu01
  • EUR 395.68
  • EUR 209.00
  • EUR 1208.80
  • EUR 469.60
  • EUR 839.20
  • EUR 328.00
  • EUR 2872.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Antitrypsin Related Protein expressed in: E.coli

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