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HNS Antibody

HNS Antibody

 

Synonyms Anti-Human IgG Fc Monoclonal Secondary Antibody (Min X Ms, Rt, Rb, Ch, Gt)
Description Generally, goat anti-human or donkey anti-human IgG polyclonal antibodies are used as the secondary antibody to detect human primary antibodies. However, since polyclonal antibodies can recognize many epitopes, the background and the cross reactivity in the assays is usually high, making the results hard to interpret.
To minimize the background and cross reactivity and improve the lot-to-lot consistency, a unique GenScript Mouse Anti-Human IgG Fc Antibody (50B4A9)[HRP], mAb has been developed to be used as a secondary antibody. The superiority of this antibody is that it can be used as an idiotype antibody to detect drug metabolism in vivo.
Host Species Mouse
Antigen Species Human
Conjugation Peroxidase (Horseradish)
Immunogen Human IgG(H&L)
Purification Protein A affinity column

 

Working concentrations for specific applications should be determined by the investigator. The appropriate concentration may be affected by primary antibody affinity, antigen concentration, sensitivity of the detection method, temperature, length of incubation, and other factors. The suitability of this antibody for applications other than those listed below has not been determined. The following concentration ranges are recommended for this product.

 

Anti-NHS antibodies are offered by many suppliers. This target gene encodes the protein ‘NHS actin remodeling regulator’ in humans and can also be referred to as CTRCT40, CXN, SCML1, Nance-Horan syndrome protein, and Nance-Horan syndrome (congenital cataracts and dental anomalies) . Structurally, the protein mass is reported to be 179.1 kilodaltons. Canine, porcine, monkey, rat and rat orthologues can also be found, depending on the gene name. For more comprehensive antibody product information (such as immunogen, specificity, application, and more), visit the supplier page.

hns, Polyclonal Antibody
hns, Polyclonal Antibody

Summary
Histone-like nucleoid structuring protein (H-NS) is a modular protein that binds to bacterial nucleoids. We used chromatin immunoprecipitation to determine the binding sites of H-NS and RNA polymerase on the Salmonella enterica serovar Typhimurium chromosomes. We found that H-NS does not bind to actively transcribed genes and does not co-localize with RNA polymerase. This suggests that H-NS silences gene expression primarily by restricting the access of RNA polymerase to DNA. H-NS was previously shown to preferentially bind to curved DNA in vitro. Indeed, at the genomic level we found that the level of H–NS binding correlates better with the AT-content of DNA. This is likely to have evolutionary consequences as we show that H-NS binds to several Salmonella genes acquired by lateral gene transfer, and acts as a gene silencer. Removal of H-NS from the cell leads to uncontrolled expression of several Salmonella pathogenicity islands, and we demonstrate that this has deleterious consequences for bacterial fitness. Our discovery of this novel role for H-NS may have implications for the acquisition of foreign genes by enteric bacteria.

Summary
In recent decades, gene silencing has been well characterized in plants and animals, and includes the prevention of transcription by DNA-methylation and histone-modification, or interference with translation by small RNA molecules. This issue of PLoS Pathogens reports the discovery that global gene silencing also occurs in bacteria. The novel mechanism is mediated by the highly abundant histone-like nucleoid structuring protein (H-NS), which blocks the expression of 254 genes in wild-type Salmonella. . Many of these genes were acquired through horizontal gene transfer, including pathogenicity islands, and are silenced by the binding of AT-rich chromosomal regions of H-NS. The study shows that H-NS inhibits uncontrolled transcription of genes within pathogenicity islands to ensure that bacterial fitness is maintained. It has been suggested that H-NS plays a role in bacterial growth by affecting both the acquisition and maintenance of foreign DNA.

 

 

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  • EUR 1845.00
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